Brain Injury Research

Amy Wagner, MD investigates the impact of an individual’s genetics and biomarkers on treatment and outcome after TBI with the intention of laying solid groundwork for a “personalized medicine” approach to treatment and rehabilitation. She has coined the term rehabilomics” to define this relatively new field of study that involves the rehabilitation-relevant properties of biomarkers and biologics as related to function, prognosis, treatment, and recovery. Projects include:

  • Genomic variablility and symptomatology after TBI
  • Developing cognitive training and rehabilitation paradigms for experimentatl TBI
  • Rehabiliomics: revolutionizing 21st century care and research, TBI model system center

Anthony E. Kline, PhD focuses his research on the effects of TBI on neurobehavioral pathways and recovery of motor and cognitive function. Dr. Kline’s laboratory at the Safar Center for Resuscitation Research (SRCC) utilizes a controlled cortical impact (CCI) injury model to produce motor and cognitive deficits in rodents mimicking those seen in human TBI patients. Therapeutic strategies such as pharmacotherapies, environmental enrichment, and their combination are subsequently provided in an attempt to restore function and/or reduce TBI-induced deficits. Projects include:

  • Mapping lipid oxidation on TBI by mass spectrometric imaging
  • Understading the impact of anti-psychotic drugs on recovery after TBI
  • Environmental enrichment and cholenergic mechanisms after TBI

Corina O. Bondi, PhD joined the department in 2014 after completing a postdoctoral fellowship under the mentorship of Dr. Anthony E. Kline. Using highly sensitive and clinically relevant behavioral tests, such as the attentional set-shifting test, her research program is focused on characterizing complex cognitive processing deficits in experimental models of traumatic brain injury. Dr. Bondi’s research interests and long-term goals include: 

  • Behavioral, molecular and neurochemical alterations after experimental brain trauma
  • Identifying novel treatment and rehabilitative approaches for frontal cortex-related cognitive dysfunction.