Anthony E. Kline, PhD

Anthony E. Kline, PhD is a tenured professor in the Department of Physical Medicine & Rehabilitation and associate director of Rehabilitation Research at the Safar Center for Resuscitation Research (SCRR) at the University of Pittsburgh. In addition, Dr. Kline holds secondary appointments in the Departments of Critical Care Medicine and Psychology and is a member of the training faculty in both the Center for Neuroscience (CNUP) and the Center for the Neural Basis of Cognition (CNBC). Dr. Kline is also co-director of the CNUP Summer Undergraduate Research Program.

Dr. Kline is a current member of the New Jersey Commission on Brain Injury Research. He is a Senior Editor for the journal Brain Research (Neurobiology of Disease) and Section Editor (Cognition and Behaviour) for BMC Neuroscience. He also serves on the editorial boards for the Journal of Neurotrauma and Restorative Neurology and Neuroscience. Dr. Kline is an International Behavioral Neuroscience Society Fellow. Dr Kline is the current treasurer for the National Neurotrauma Society (a position he held last year as well) and is President-elect for 2018.


Specialized Areas of Interest
Motor and cognitive recovery after traumatic brain injury, pharmacotherapy, environmental enrichment, neurotransmitters, neural plasticity

Education & Training
BA, Psychology, University of New Mexico, 1989
MA, Psychology/Behavioral Neuroscience, University of Colorado, 1996
PhD, Psychology/Behavioral Neuroscience, University of Colorado, 1998

Honors and Awards
Distinguished Mentor Award, Faculty for Undergraduate Neuroscience (FUN), 2015
Fellow, International Behavioral and Neuroscience Society, 2013
Alumni Achievement Award for Research, American Psychological Association and Diversity
President's Citation-Presentation, American Academy of PM&R, 2005
Faculty Honoree, 2010, 2014

Research Activities
Dr. Kline’s research includes neurobehavioral recovery and learning after experimental traumatic brain injury (TBI). Therapeutic strategies that include pharmacotherapy and environmental enrichment are utilized alone or in combination in an attempt to restore function and/or attenuate TBI-induced deficits. Another interest is the evaluation of pharmacological agents that may hinder the recovery process after TBI (e.g., antipsychotics). The long-term goals of the laboratory are to develop therapies that facilitate functional recovery after TBI and to elucidate potential mechanisms for the observed effects. Additionally, the evaluation of therapies shown to benefit outcome in adult models of TBI are being investigated in pediatric models. Dr. Kline’s research is funded by the NIH.

Dr. Kline is an active research mentor for students at all levels of training. Several of his recent trainees have gone on to graduate school or medical programs. He recently received the Distinguished Mentor Award from the Faculty for Undergraduate Neuroscience (FUN) of the Society for Neuroscience (SfN). The Mentor Award is given to a FUN member, in recognition of significant contributions as a mentor for young neuroscientists.

Professional Organization Membership
American Academy of Physical Medicine & Rehabilitation
Association of Academic Physiatrists
Faculty for Undergraduate Neuroscience
International Behavioral Neuroscience Society
International Brain Injury Association
National Neurotrauma Society
North American Brain Injury Association
Society for Advancement of Chicanos and Native Americans in Science
Society for Neuroscience
Women in Neurotrauma Research

Selected Publications
Combination therapies for neurobehavioral and cognitive recovery after experimental traumatic brain injury: Is more better? Kline AE, Leary JB, Radabaugh HL, Cheng JP, Bondi CO. Prog Neurobiol. 2016 Jul;142:45-67. doi: 10.1016/j.pneurobio.2016.05.002. Epub 2016 May 7. Review.

5-hydroxytryptamine1A (5-HT1A) receptor agonists: A decade of empirical evidence supports their use as an efficacious therapeutic strategy for brain trauma. Cheng JP, Leary JB, Sembhi A, Edwards CM, Bondi CO, Kline AE. Brain Res. 2016 Jun 1;1640(Pt A):5-14. doi: 10.1016/j.brainres.2015.11.026. Epub 2015 Nov 21. Review.

Found in translation: Understanding the biology and behavior of experimental traumatic brain injury. Bondi CO, Semple BD, Noble-Haeusslein LJ, Osier ND, Carlson SW, Dixon CE, Giza CC, Kline AE. Neurosci Biobehav Rev. 2015 Nov;58:123-46. doi: 10.1016/j.neubiorev.2014.12.004. Epub 2014 Dec 10. Review.

A combined therapeutic regimen of buspirone and environmental enrichment is more efficacious than either alone in enhancing spatial learning in brain-injured pediatric rats. Monaco CM, Gebhardt KM, Chlebowski SM, Shaw KE, Cheng JP, Henchir JJ, Zupa MF, Kline AE. J Neurotrauma. 2014 Dec 1;31(23):1934-41. doi: 10.1089/neu.2014.3541. Epub 2014 Sep 29.

Empirical comparison of typical and atypical environmental enrichment paradigms on functional and histological outcome after experimental traumatic brain injury. Sozda CN, Hoffman AN, Olsen AS, Cheng JP, Zafonte RD, Kline AE. J Neurotrauma. 2010 Jun;27(6):1047-57. doi: 10.1089/neu.2010.1313.

Dr. Kline's publications on PubMed.